Drug interactions
Avanafil + Lisinopril
Severity: Moderate
Avanafil and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil may add to the antihypertensive effect of lisinopril. Dizziness or symptomatic hypotension can occur, particularly early in therapy.
What this interaction means in plain words
Avanafil and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Lisinopril belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects (pharmacodynamic synergism).
What to do
Confirm stable blood pressure before starting avanafil and monitor for orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avanafil and Lisinopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Avanafil with Lisinopril?
MediHelp rates the interaction as moderate. Avanafil and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil may add to the antihypertensive effect of lisinopril. Dizziness or symptomatic hypotension can occur, particularly early in therapy.
How serious is the interaction between Avanafil and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm stable blood pressure before starting avanafil and monitor for orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
