Drug interactions
Avanafil + Nifedipine
Severity: Moderate
Avanafil and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause vasodilation, so combined use can produce additive hypotension. Nifedipine is also a weak CYP3A4 substrate with little inhibitory effect, so the main concern is pharmacodynamic.
What this interaction means in plain words
Avanafil and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Nifedipine belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects (pharmacodynamic synergism).
What to do
Confirm blood pressure is stable before starting avanafil and monitor for orthostatic symptoms. Start at the lowest dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Avanafil with Nifedipine?
MediHelp rates the interaction as moderate. Avanafil and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause vasodilation, so combined use can produce additive hypotension. Nifedipine is also a weak CYP3A4 substrate with little inhibitory effect, so the main concern is pharmacodynamic.
How serious is the interaction between Avanafil and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm blood pressure is stable before starting avanafil and monitor for orthostatic symptoms. Start at the lowest dose.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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