Drug interactions
Avanafil + Nilotinib
Severity: Moderate
Avanafil and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may increase avanafil exposure, raising the risk of hypotension, flushing and priapism. Nilotinib also prolongs the QT interval, so careful use is advisable.
What this interaction means in plain words
Avanafil and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of avanafil by nilotinib reduces its clearance.
What to do
Limit avanafil to 50 mg, no more than once every 24 hours, and monitor for hypotension and prolonged erection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Avanafil with Nilotinib?
MediHelp rates the interaction as moderate. Avanafil and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may increase avanafil exposure, raising the risk of hypotension, flushing and priapism. Nilotinib also prolongs the QT interval, so careful use is advisable.
How serious is the interaction between Avanafil and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit avanafil to 50 mg, no more than once every 24 hours, and monitor for hypotension and prolonged erection.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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