Drug interactions
Avanafil + Oxcarbazepine
Severity: Minor
Avanafil and Oxcarbazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine can weakly induce CYP3A4, which may lower avanafil exposure and reduce its effect on erectile function. The effect is usually modest.
What this interaction means in plain words
Avanafil and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avanafil belongs to Genitourinary; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4-mediated metabolism of avanafil.
What to do
Assess erectile response; if efficacy is inadequate, consider a dose adjustment within labeled limits or an alternative.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Avanafil with Oxcarbazepine?
MediHelp rates the interaction as minor. Avanafil and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxcarbazepine can weakly induce CYP3A4, which may lower avanafil exposure and reduce its effect on erectile function. The effect is usually modest.
How serious is the interaction between Avanafil and Oxcarbazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess erectile response; if efficacy is inadequate, consider a dose adjustment within labeled limits or an alternative.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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