Drug interactions
Avanafil + Pazopanib
Severity: Minor
Avanafil and Pazopanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is a weak CYP3A4 inhibitor in vitro, and may modestly raise avanafil levels. Clinical significance is likely small, but adverse effects such as hypotension and headache could increase.
What this interaction means in plain words
Avanafil and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avanafil belongs to Genitourinary; Pazopanib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 reduces avanafil clearance.
What to do
No routine dose change is needed; monitor for avanafil adverse effects such as flushing, headache and hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Avanafil with Pazopanib?
MediHelp rates the interaction as minor. Avanafil and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pazopanib is a weak CYP3A4 inhibitor in vitro, and may modestly raise avanafil levels. Clinical significance is likely small, but adverse effects such as hypotension and headache could increase.
How serious is the interaction between Avanafil and Pazopanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for avanafil adverse effects such as flushing, headache and hypotension.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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