Drug interactions
Avanafil + Propranolol
Severity: Minor
Avanafil and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil may add modestly to the blood pressure lowering effect of propranolol. Significant hypotension is uncommon but possible.
What this interaction means in plain words
Avanafil and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avanafil belongs to Genitourinary; Propranolol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from PDE5 inhibition and beta-blockade.
What to do
Monitor blood pressure and symptoms after initiation; no dose adjustment is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Avanafil with Propranolol?
MediHelp rates the interaction as minor. Avanafil and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avanafil may add modestly to the blood pressure lowering effect of propranolol. Significant hypotension is uncommon but possible.
How serious is the interaction between Avanafil and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms after initiation; no dose adjustment is routinely needed.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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