Drug interactions
Avanafil + Sacubitril-valsartan
Severity: Moderate
Avanafil and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil has vasodilating effects and can lower blood pressure, which adds to the effect of sacubitril/valsartan. Symptomatic hypotension may occur.
What this interaction means in plain words
Avanafil and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition with angiotensin receptor blockade and neprilysin inhibition.
What to do
Start with the lowest avanafil dose and monitor blood pressure and orthostatic symptoms. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Avanafil and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil has vasodilating effects and can lower blood pressure, which adds to the effect of sacubitril/valsartan. Symptomatic hypotension may occur.
How serious is the interaction between Avanafil and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest avanafil dose and monitor blood pressure and orthostatic symptoms. Counsel patients to rise slowly.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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