Drug interactions
Avanafil + Timolol
Severity: Minor
Avanafil and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol may add slightly to the blood pressure lowering effect of avanafil. Clinically significant hypotension is uncommon.
What this interaction means in plain words
Avanafil and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avanafil belongs to Genitourinary; Timolol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from PDE5 inhibition and beta-blockade.
What to do
Monitor blood pressure after initiation; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Avanafil with Timolol?
MediHelp rates the interaction as minor. Avanafil and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic timolol may add slightly to the blood pressure lowering effect of avanafil. Clinically significant hypotension is uncommon.
How serious is the interaction between Avanafil and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after initiation; no routine dose change is needed.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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