Drug interactions
Avapritinib + Bicalutamide
Severity: Minor
Avapritinib and Bicalutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide is at most a weak CYP3A4 inhibitor, so any rise in avapritinib exposure is probably small. The legacy classification as a moderate inhibitor is not well supported clinically.
What this interaction means in plain words
Avapritinib and Bicalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Bicalutamide belongs to Endocrine.
Why it happens
Weak, possible CYP3A4 inhibition by bicalutamide may slightly raise avapritinib levels.
What to do
No dose change is usually needed; monitor for avapritinib adverse effects such as cognitive effects and bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Bicalutamide?
MediHelp rates the interaction as minor. Avapritinib and Bicalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide is at most a weak CYP3A4 inhibitor, so any rise in avapritinib exposure is probably small. The legacy classification as a moderate inhibitor is not well supported clinically.
How serious is the interaction between Avapritinib and Bicalutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for avapritinib adverse effects such as cognitive effects and bleeding.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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