Drug interactions
Avapritinib + Bortezomib
Severity: Minor
Avapritinib and Bortezomib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is not a recognized clinically relevant CYP3A4 inhibitor, so a meaningful increase in avapritinib exposure is not expected. Both drugs can cause cytopenias, which is the more relevant concern.
What this interaction means in plain words
Avapritinib and Bortezomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Bortezomib belongs to Oncology.
Why it happens
No established pharmacokinetic mechanism; possible additive hematologic toxicity.
What to do
No dose adjustment is needed. Monitor blood counts and for avapritinib adverse effects such as cognitive effects and bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Bortezomib?
MediHelp rates the interaction as minor. Avapritinib and Bortezomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib is not a recognized clinically relevant CYP3A4 inhibitor, so a meaningful increase in avapritinib exposure is not expected. Both drugs can cause cytopenias, which is the more relevant concern.
How serious is the interaction between Avapritinib and Bortezomib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor blood counts and for avapritinib adverse effects such as cognitive effects and bleeding.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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