Drug interactions
Avapritinib + Clorazepate
Severity: Moderate
Avapritinib and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence. Adding clorazepate may worsen these CNS effects.
What this interaction means in plain words
Avapritinib and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Clorazepate belongs to Central Nervous System.
Why it happens
Additive CNS effects; avapritinib's cognitive toxicity mechanism is not fully defined.
What to do
Monitor for cognitive impairment and sedation, and reduce or stop the benzodiazepine if these develop. Follow avapritinib dose-modification guidance for CNS adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Clorazepate?
MediHelp rates the interaction as moderate. Avapritinib and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence. Adding clorazepate may worsen these CNS effects.
How serious is the interaction between Avapritinib and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive impairment and sedation, and reduce or stop the benzodiazepine if these develop. Follow avapritinib dose-modification guidance for CNS adverse effects.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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