Drug interactions
Avapritinib + Crizotinib
Severity: Major
Avapritinib and Crizotinib: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may raise avapritinib exposure. This may increase avapritinib toxicities such as cognitive effects, intracranial hemorrhage and edema.
What this interaction means in plain words
Avapritinib and Crizotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing avapritinib clearance.
What to do
Avoid the combination; if unavoidable, reduce the avapritinib dose per labeling and monitor for neurologic and bleeding adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Crizotinib?
MediHelp rates the interaction as major. Avapritinib and Crizotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib is a moderate CYP3A4 inhibitor and may raise avapritinib exposure. This may increase avapritinib toxicities such as cognitive effects, intracranial hemorrhage and edema.
How serious is the interaction between Avapritinib and Crizotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if unavoidable, reduce the avapritinib dose per labeling and monitor for neurologic and bleeding adverse effects.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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