Drug interactions
Avapritinib + Dasatinib
Severity: Moderate
Avapritinib and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib may modestly increase avapritinib exposure through CYP3A4 inhibition. Avapritinib adverse effects include intracranial hemorrhage, cognitive effects and cytopenias, and dasatinib adds bleeding and myelosuppression risk.
What this interaction means in plain words
Avapritinib and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Dasatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by dasatinib reduces avapritinib clearance, with overlapping hematologic and bleeding toxicity.
What to do
Monitor blood counts and watch for bleeding and cognitive changes. Reduce the avapritinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Dasatinib?
MediHelp rates the interaction as moderate. Avapritinib and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib may modestly increase avapritinib exposure through CYP3A4 inhibition. Avapritinib adverse effects include intracranial hemorrhage, cognitive effects and cytopenias, and dasatinib adds bleeding and myelosuppression risk.
How serious is the interaction between Avapritinib and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for bleeding and cognitive changes. Reduce the avapritinib dose if toxicity occurs.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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