Drug interactions
Avapritinib + Dronedarone
Severity: Major
Avapritinib and Dronedarone: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and can raise avapritinib concentrations. This may increase adverse effects such as cognitive effects, intracranial hemorrhage and fluid retention.
What this interaction means in plain words
Avapritinib and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of avapritinib by dronedarone.
What to do
Avoid the combination where possible. If it is needed, reduce the avapritinib dose according to labeling and monitor for cognitive changes and bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Dronedarone?
MediHelp rates the interaction as major. Avapritinib and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone is a moderate CYP3A4 inhibitor and can raise avapritinib concentrations. This may increase adverse effects such as cognitive effects, intracranial hemorrhage and fluid retention.
How serious is the interaction between Avapritinib and Dronedarone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is needed, reduce the avapritinib dose according to labeling and monitor for cognitive changes and bleeding.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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