Drug interactions
Avapritinib + Flibanserin
Severity: Moderate
Avapritinib and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause somnolence and cognitive effects, so together they may increase sedation and impair alertness. Avapritinib is also a CYP3A4 substrate with some inhibitory effect.
What this interaction means in plain words
Avapritinib and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depressant effects.
What to do
Advise patients to avoid driving until the response is known, and monitor for excessive sedation and cognitive effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Flibanserin?
MediHelp rates the interaction as moderate. Avapritinib and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause somnolence and cognitive effects, so together they may increase sedation and impair alertness. Avapritinib is also a CYP3A4 substrate with some inhibitory effect.
How serious is the interaction between Avapritinib and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving until the response is known, and monitor for excessive sedation and cognitive effects.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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