Drug interactions
Avapritinib + Fluvoxamine
Severity: Moderate
Avapritinib and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is a weak to moderate CYP3A4 inhibitor and may increase avapritinib exposure, raising the risk of cognitive effects, intracranial hemorrhage and other toxicities.
What this interaction means in plain words
Avapritinib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by fluvoxamine reduces avapritinib clearance.
What to do
Prefer an alternative antidepressant. If needed, reduce the avapritinib dose per labeling and monitor for cognitive and bleeding adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Fluvoxamine?
MediHelp rates the interaction as moderate. Avapritinib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine is a weak to moderate CYP3A4 inhibitor and may increase avapritinib exposure, raising the risk of cognitive effects, intracranial hemorrhage and other toxicities.
How serious is the interaction between Avapritinib and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antidepressant. If needed, reduce the avapritinib dose per labeling and monitor for cognitive and bleeding adverse effects.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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