Drug interactions
Avapritinib + Haloperidol
Severity: Moderate
Avapritinib and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a weak to moderate CYP3A4 inhibitor and may raise avapritinib exposure, increasing its adverse effects such as cognitive effects, intracranial hemorrhage and edema. The significance of this is uncertain, but it is a predicted interaction.
What this interaction means in plain words
Avapritinib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Haloperidol belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated avapritinib metabolism by haloperidol.
What to do
Monitor for avapritinib adverse effects, especially cognitive changes and bleeding. Consider an alternative antipsychotic or reduce the avapritinib dose per labeling if a moderate inhibitor is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Haloperidol?
MediHelp rates the interaction as moderate. Avapritinib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is a weak to moderate CYP3A4 inhibitor and may raise avapritinib exposure, increasing its adverse effects such as cognitive effects, intracranial hemorrhage and edema. The significance of this is uncertain, but it is a predicted interaction.
How serious is the interaction between Avapritinib and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for avapritinib adverse effects, especially cognitive changes and bleeding. Consider an alternative antipsychotic or reduce the avapritinib dose per labeling if a moderate inhibitor is required.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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