Drug interactions
Avapritinib + Hydroxyzine
Severity: Moderate
Avapritinib and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib commonly causes cognitive effects such as memory impairment, confusion and drowsiness, and hydroxyzine may add to these. Combined use may worsen impaired alertness and falls risk.
What this interaction means in plain words
Avapritinib and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Monitor cognition and sedation, and avoid giving hydroxyzine routinely. Dose reduction or interruption of avapritinib may be needed if cognitive effects worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Hydroxyzine?
MediHelp rates the interaction as moderate. Avapritinib and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib commonly causes cognitive effects such as memory impairment, confusion and drowsiness, and hydroxyzine may add to these. Combined use may worsen impaired alertness and falls risk.
How serious is the interaction between Avapritinib and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and sedation, and avoid giving hydroxyzine routinely. Dose reduction or interruption of avapritinib may be needed if cognitive effects worsen.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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