Drug interactions
Avapritinib + Itraconazole
Severity: Major
Avapritinib and Itraconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole substantially raises avapritinib exposure, which may increase intracranial hemorrhage, cognitive effects, edema and other toxicities.
What this interaction means in plain words
Avapritinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole strongly inhibits CYP3A4, the main metabolic pathway of avapritinib.
What to do
Avoid the combination and use an antifungal with minimal CYP3A inhibition. If unavoidable, follow labeling for avapritinib dose reduction and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Itraconazole?
MediHelp rates the interaction as major. Avapritinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole substantially raises avapritinib exposure, which may increase intracranial hemorrhage, cognitive effects, edema and other toxicities.
How serious is the interaction between Avapritinib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antifungal with minimal CYP3A inhibition. If unavoidable, follow labeling for avapritinib dose reduction and monitor for toxicity.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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