Drug interactions
Avapritinib + Liposomal doxorubicin
Severity: Minor
Avapritinib and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin has been reported to inhibit CYP3A4 in some references, which could raise avapritinib exposure. Clinical evidence is lacking and liposomal doxorubicin is unlikely to inhibit CYP3A4 meaningfully. Cognitive effects or bleeding with avapritinib would be the concern.
What this interaction means in plain words
Avapritinib and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Liposomal doxorubicin belongs to Oncology.
Why it happens
Theoretical CYP3A4 inhibition by doxorubicin may raise avapritinib levels; not clinically established.
What to do
No adjustment is needed; monitor for avapritinib toxicity such as cognitive effects and bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Avapritinib and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin has been reported to inhibit CYP3A4 in some references, which could raise avapritinib exposure. Clinical evidence is lacking and liposomal doxorubicin is unlikely to inhibit CYP3A4 meaningfully. Cognitive effects or bleeding with avapritinib would be the concern.
How serious is the interaction between Avapritinib and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor for avapritinib toxicity such as cognitive effects and bleeding.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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