Drug interactions
Avapritinib + Meperidine
Severity: Moderate
Avapritinib and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as confusion, drowsiness and memory impairment. Combined with meperidine, CNS impairment may be increased.
What this interaction means in plain words
Avapritinib and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS effects.
What to do
Monitor cognition and sedation, and reduce opioid doses if impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Meperidine?
MediHelp rates the interaction as moderate. Avapritinib and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as confusion, drowsiness and memory impairment. Combined with meperidine, CNS impairment may be increased.
How serious is the interaction between Avapritinib and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and sedation, and reduce opioid doses if impairment develops.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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