Drug interactions
Avapritinib + Midazolam
Severity: Moderate
Avapritinib and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib causes dose-related cognitive effects and somnolence, and combining it with midazolam adds to sedation. Midazolam is not a meaningful CYP3A4 inhibitor, so the pharmacokinetic effect on avapritinib is likely small. Avapritinib is a weak-to-moderate CYP3A4 inhibitor/inducer and may alter midazolam exposure.
What this interaction means in plain words
Avapritinib and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible CYP3A4-mediated pharmacokinetic changes.
What to do
Monitor sedation and cognitive function and use lower midazolam doses with careful titration. Reassess avapritinib dosing if cognitive effects worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Midazolam?
MediHelp rates the interaction as moderate. Avapritinib and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib causes dose-related cognitive effects and somnolence, and combining it with midazolam adds to sedation. Midazolam is not a meaningful CYP3A4 inhibitor, so the pharmacokinetic effect on avapritinib is likely small. Avapritinib is a weak-to-moderate CYP3A4 inhibitor/inducer and may alter midazolam exposure.
How serious is the interaction between Avapritinib and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and cognitive function and use lower midazolam doses with careful titration. Reassess avapritinib dosing if cognitive effects worsen.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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