Drug interactions
Avapritinib + Pentazocine
Severity: Moderate
Avapritinib and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and pentazocine is a sedating opioid. Together they may increase drowsiness, confusion and impaired concentration.
What this interaction means in plain words
Avapritinib and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for sedation and cognitive changes and reduce the opioid dose if impairment develops. Advise caution with driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Pentazocine?
MediHelp rates the interaction as moderate. Avapritinib and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and pentazocine is a sedating opioid. Together they may increase drowsiness, confusion and impaired concentration.
How serious is the interaction between Avapritinib and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes and reduce the opioid dose if impairment develops. Advise caution with driving and machinery.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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