Drug interactions
Avapritinib + Perphenazine
Severity: Moderate
Avapritinib and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as somnolence, memory impairment and confusion, while perphenazine is sedating. Together they may increase drowsiness and cognitive impairment, affecting safety and daily functioning.
What this interaction means in plain words
Avapritinib and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant pharmacodynamic effects.
What to do
Monitor for excessive sedation and cognitive changes and advise patients to avoid driving or hazardous tasks until response is known. Reduce doses or interrupt avapritinib per labeling if cognitive adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avapritinib and Perphenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Perphenazine?
MediHelp rates the interaction as moderate. Avapritinib and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as somnolence, memory impairment and confusion, while perphenazine is sedating. Together they may increase drowsiness and cognitive impairment, affecting safety and daily functioning.
How serious is the interaction between Avapritinib and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and cognitive changes and advise patients to avoid driving or hazardous tasks until response is known. Reduce doses or interrupt avapritinib per labeling if cognitive adverse effects emerge.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
