Drug interactions
Avapritinib + Sirolimus
Severity: Minor
Avapritinib and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus is not a recognized meaningful CYP3A4 inhibitor, so an increase in avapritinib exposure is unlikely and largely theoretical. Both agents have adverse effects that overlap, such as edema and cytopenias.
What this interaction means in plain words
Avapritinib and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Theoretical CYP3A4 interaction; not well established.
What to do
No dose adjustment is usually needed. Monitor blood counts and watch for edema or cognitive effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Sirolimus?
MediHelp rates the interaction as minor. Avapritinib and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus is not a recognized meaningful CYP3A4 inhibitor, so an increase in avapritinib exposure is unlikely and largely theoretical. Both agents have adverse effects that overlap, such as edema and cytopenias.
How serious is the interaction between Avapritinib and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor blood counts and watch for edema or cognitive effects.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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