Drug interactions
Avapritinib + Voriconazole
Severity: Major
Avapritinib and Voriconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole, a strong CYP3A4 inhibitor, markedly increases avapritinib exposure. This raises the risk of avapritinib toxicities such as intracranial hemorrhage, cognitive effects, edema and QT prolongation.
What this interaction means in plain words
Avapritinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of avapritinib by voriconazole.
What to do
Avoid concomitant use and choose an antifungal with weaker CYP3A4 inhibition if possible. If it cannot be avoided, follow labeling for a reduced avapritinib dose and monitor closely for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avapritinib and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Voriconazole?
MediHelp rates the interaction as major. Avapritinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole, a strong CYP3A4 inhibitor, markedly increases avapritinib exposure. This raises the risk of avapritinib toxicities such as intracranial hemorrhage, cognitive effects, edema and QT prolongation.
How serious is the interaction between Avapritinib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose an antifungal with weaker CYP3A4 inhibition if possible. If it cannot be avoided, follow labeling for a reduced avapritinib dose and monitor closely for adverse effects.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
