Drug interactions
Axitinib + Sodium zirconium cyclosilicate
Severity: Minor
Axitinib and Sodium zirconium cyclosilicate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate transiently raises gastric pH, which may slightly lower axitinib absorption. Axitinib's solubility is only modestly pH-dependent, so the effect is likely small.
What this interaction means in plain words
Axitinib and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH may reduce axitinib dissolution and absorption.
What to do
Separate dosing by at least 2 hours, giving axitinib before or after sodium zirconium cyclosilicate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Axitinib with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as minor. Axitinib and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium zirconium cyclosilicate transiently raises gastric pH, which may slightly lower axitinib absorption. Axitinib's solubility is only modestly pH-dependent, so the effect is likely small.
How serious is the interaction between Axitinib and Sodium zirconium cyclosilicate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing by at least 2 hours, giving axitinib before or after sodium zirconium cyclosilicate.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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