Drug interactions
Azathioprine + Golimumab
Severity: Major
Azathioprine and Golimumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined therapy increases the risk of serious infection and lymphoma, including rare hepatosplenic T-cell lymphoma. It is sometimes used intentionally in inflammatory disease.
What this interaction means in plain words
Azathioprine and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Golimumab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from TNF-alpha blockade and thiopurine effects.
What to do
Use only when benefit is clear, and monitor for infection and blood count abnormalities. Reassess ongoing need for the thiopurine regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Golimumab?
MediHelp rates the interaction as major. Azathioprine and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combined therapy increases the risk of serious infection and lymphoma, including rare hepatosplenic T-cell lymphoma. It is sometimes used intentionally in inflammatory disease.
How serious is the interaction between Azathioprine and Golimumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when benefit is clear, and monitor for infection and blood count abnormalities. Reassess ongoing need for the thiopurine regularly.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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