Drug interactions
Azelastine + Chlorpromazine
Severity: Moderate
Azelastine and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is strongly sedating and anticholinergic, and azelastine may add to drowsiness. The combination may increase sedation, dizziness and hypotension.
What this interaction means in plain words
Azelastine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1 and other receptor antagonism.
What to do
Monitor for oversedation and orthostatic hypotension, especially in older patients. Advise against driving until the effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Azelastine with Chlorpromazine?
MediHelp rates the interaction as moderate. Azelastine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is strongly sedating and anticholinergic, and azelastine may add to drowsiness. The combination may increase sedation, dizziness and hypotension.
How serious is the interaction between Azelastine and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic hypotension, especially in older patients. Advise against driving until the effect is known.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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