Drug interactions
Azelastine + Prochlorperazine
Severity: Moderate
Azelastine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine is sedating and combining it with azelastine can deepen drowsiness and reduce psychomotor performance. The effect is more notable in the elderly and with oral or high-dose azelastine.
What this interaction means in plain words
Azelastine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and phenothiazine antihistaminic and antidopaminergic effects.
What to do
Monitor sedation and advise against driving until tolerance is known. Reduce doses or choose a less sedating antihistamine if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Azelastine with Prochlorperazine?
MediHelp rates the interaction as moderate. Azelastine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine is sedating and combining it with azelastine can deepen drowsiness and reduce psychomotor performance. The effect is more notable in the elderly and with oral or high-dose azelastine.
How serious is the interaction between Azelastine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and advise against driving until tolerance is known. Reduce doses or choose a less sedating antihistamine if excessive drowsiness occurs.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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