Drug interactions
Azelastine-fluticasone + Dantrolene
Severity: Moderate
Azelastine-fluticasone and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene causes drowsiness and muscle weakness, and azelastine can add to sedation, particularly with the nasal combination absorbed systemically. The result may be impaired alertness and psychomotor performance.
What this interaction means in plain words
Azelastine-fluticasone and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from the sedating antihistamine azelastine and dantrolene.
What to do
Counsel patients about drowsiness and advise against driving or operating machinery until the response is known. Reduce the dose or stop azelastine if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Dantrolene
Frequently asked questions
Can I take Azelastine-fluticasone with Dantrolene?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene causes drowsiness and muscle weakness, and azelastine can add to sedation, particularly with the nasal combination absorbed systemically. The result may be impaired alertness and psychomotor performance.
How serious is the interaction between Azelastine-fluticasone and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and advise against driving or operating machinery until the response is known. Reduce the dose or stop azelastine if excessive sedation occurs.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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