Drug interactions
Azelastine-fluticasone + Fenfluramine
Severity: Minor
Azelastine-fluticasone and Fenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine can cause somnolence and sedation in some patients, and azelastine may add drowsiness. The net effect is uncertain and probably small with intranasal use.
What this interaction means in plain words
Azelastine-fluticasone and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Fenfluramine belongs to Central Nervous System.
Why it happens
Possible additive CNS effects from azelastine's antihistaminic sedation and fenfluramine's serotonergic activity; the interaction is not firmly established.
What to do
Ask patients about daytime drowsiness when starting the nasal spray. Advise caution with driving if sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Azelastine-fluticasone with Fenfluramine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenfluramine can cause somnolence and sedation in some patients, and azelastine may add drowsiness. The net effect is uncertain and probably small with intranasal use.
How serious is the interaction between Azelastine-fluticasone and Fenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about daytime drowsiness when starting the nasal spray. Advise caution with driving if sedation occurs.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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