Drug interactions
Azelastine-fluticasone + Finerenone
Severity: Minor
Azelastine-fluticasone and Finerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure with intranasal use. Higher finerenone levels increase the risk of hyperkalemia and renal effects.
What this interaction means in plain words
Azelastine-fluticasone and Finerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Finerenone belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4 reduces finerenone metabolism and increases its exposure.
What to do
Monitor serum potassium and renal function when the combination is started or changed. Adjust finerenone dose if potassium rises.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Finerenone?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Finerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure with intranasal use. Higher finerenone levels increase the risk of hyperkalemia and renal effects.
How serious is the interaction between Azelastine-fluticasone and Finerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when the combination is started or changed. Adjust finerenone dose if potassium rises.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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