Drug interactions
Azelastine-fluticasone + Modafinil
Severity: Minor
Azelastine-fluticasone and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine can cause somnolence while modafinil promotes wakefulness, so their effects on alertness oppose each other. No important harmful interaction is expected.
What this interaction means in plain words
Azelastine-fluticasone and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Modafinil belongs to Central Nervous System.
Why it happens
Opposing effects on CNS arousal; no established pharmacokinetic interaction.
What to do
No specific action is needed; advise the patient that drowsiness from azelastine may still occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azelastine-fluticasone and Modafinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Modafinil
Frequently asked questions
Can I take Azelastine-fluticasone with Modafinil?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine can cause somnolence while modafinil promotes wakefulness, so their effects on alertness oppose each other. No important harmful interaction is expected.
How serious is the interaction between Azelastine-fluticasone and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; advise the patient that drowsiness from azelastine may still occur.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
