Drug interactions
Azelastine-fluticasone + Oxycodone
Severity: Moderate
Azelastine-fluticasone and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxycodone causes sedation and respiratory depression, and azelastine may add to drowsiness. Combined use may increase CNS depression and impair alertness.
What this interaction means in plain words
Azelastine-fluticasone and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and antihistamine sedation.
What to do
Monitor for excess sedation and slowed breathing, especially when starting or increasing oxycodone. Advise avoidance of alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Oxycodone?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxycodone causes sedation and respiratory depression, and azelastine may add to drowsiness. Combined use may increase CNS depression and impair alertness.
How serious is the interaction between Azelastine-fluticasone and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and slowed breathing, especially when starting or increasing oxycodone. Advise avoidance of alcohol and driving.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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