Drug interactions
Azelastine-fluticasone + Risperidone
Severity: Minor
Azelastine-fluticasone and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine may add to the sedating effect of risperidone. Nasal dosing gives low systemic levels, so the interaction is usually mild.
What this interaction means in plain words
Azelastine-fluticasone and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from antihistaminic and antipsychotic effects.
What to do
Advise patients to monitor for excess drowsiness and avoid alcohol. No dose adjustment is normally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Azelastine-fluticasone with Risperidone?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine may add to the sedating effect of risperidone. Nasal dosing gives low systemic levels, so the interaction is usually mild.
How serious is the interaction between Azelastine-fluticasone and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor for excess drowsiness and avoid alcohol. No dose adjustment is normally needed.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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