Drug interactions
Azelastine-fluticasone + Tramadol
Severity: Moderate
Azelastine-fluticasone and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine may add to the sedation caused by tramadol. Systemic azelastine exposure from nasal dosing is low, but opioid-related CNS depression can be additive.
What this interaction means in plain words
Azelastine-fluticasone and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid and antihistamine effects.
What to do
Monitor for excess drowsiness or slowed breathing, especially when starting therapy. Advise avoiding alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Tramadol?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine may add to the sedation caused by tramadol. Systemic azelastine exposure from nasal dosing is low, but opioid-related CNS depression can be additive.
How serious is the interaction between Azelastine-fluticasone and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness or slowed breathing, especially when starting therapy. Advise avoiding alcohol and other sedatives.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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