Drug interactions
Azelastine-fluticasone + Trimipramine
Severity: Minor
Azelastine-fluticasone and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is strongly sedating and antihistaminic, and azelastine may add to the drowsiness and anticholinergic burden. The effect is generally modest given low systemic azelastine levels.
What this interaction means in plain words
Azelastine-fluticasone and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 receptor antagonism.
What to do
Advise patients to watch for excess sedation and avoid alcohol. Reduce spray use if sedation becomes troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Trimipramine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimipramine is strongly sedating and antihistaminic, and azelastine may add to the drowsiness and anticholinergic burden. The effect is generally modest given low systemic azelastine levels.
How serious is the interaction between Azelastine-fluticasone and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for excess sedation and avoid alcohol. Reduce spray use if sedation becomes troublesome.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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