Drug interactions
Azilsartan + Canagliflozin
Severity: Moderate
Azilsartan and Canagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin does not typically cause hyperkalemia and may have a mild potassium-lowering effect, although volume depletion with an ARB can cause hypotension and reduced renal function. Canagliflozin labeling noted hyperkalemia in patients with reduced renal function on potassium-raising drugs.
What this interaction means in plain words
Azilsartan and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
Why it happens
Volume depletion from SGLT2 inhibition plus ARB-mediated reduction in glomerular pressure may cause hypotension and renal function decline, with potassium rise in susceptible patients.
What to do
Monitor blood pressure, renal function and potassium after starting canagliflozin, and correct volume depletion before initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Azilsartan with Canagliflozin?
MediHelp rates the interaction as moderate. Azilsartan and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin does not typically cause hyperkalemia and may have a mild potassium-lowering effect, although volume depletion with an ARB can cause hypotension and reduced renal function. Canagliflozin labeling noted hyperkalemia in patients with reduced renal function on potassium-raising drugs.
How serious is the interaction between Azilsartan and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium after starting canagliflozin, and correct volume depletion before initiation.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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