Drug interactions
Azilsartan-chlorthalidone + Bumetanide
Severity: Moderate
Azilsartan-chlorthalidone and Bumetanide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone and bumetanide act at different nephron sites and together produce strong sequential natriuresis. This can cause marked potassium and magnesium loss, volume depletion, hypotension and prerenal azotemia.
What this interaction means in plain words
Azilsartan-chlorthalidone and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Bumetanide belongs to Cardiovascular.
Why it happens
Additive diuretic effect from thiazide-like and loop diuretic action, increasing urinary potassium, sodium and water loss.
What to do
Monitor serum potassium, magnesium, sodium and creatinine, and check volume status and blood pressure after starting or changing doses. Replace electrolytes as needed and reduce diuretic doses if hypovolemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Bumetanide
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Bumetanide?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone and bumetanide act at different nephron sites and together produce strong sequential natriuresis. This can cause marked potassium and magnesium loss, volume depletion, hypotension and prerenal azotemia.
How serious is the interaction between Azilsartan-chlorthalidone and Bumetanide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium, sodium and creatinine, and check volume status and blood pressure after starting or changing doses. Replace electrolytes as needed and reduce diuretic doses if hypovolemia develops.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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