Drug interactions
Azilsartan-chlorthalidone + Digoxin
Severity: Moderate
Azilsartan-chlorthalidone and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and can precipitate arrhythmias and digoxin toxicity. Azilsartan may raise potassium and partly offset this, but the net effect is unpredictable.
What this interaction means in plain words
Azilsartan-chlorthalidone and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia and hypomagnesemia enhance digoxin binding to Na+/K+-ATPase and increase its toxic effects.
What to do
Monitor potassium and magnesium regularly and keep them in the normal range. Check digoxin levels and watch for signs of toxicity such as nausea, visual changes and arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Digoxin?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and can precipitate arrhythmias and digoxin toxicity. Azilsartan may raise potassium and partly offset this, but the net effect is unpredictable.
How serious is the interaction between Azilsartan-chlorthalidone and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium regularly and keep them in the normal range. Check digoxin levels and watch for signs of toxicity such as nausea, visual changes and arrhythmias.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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