Drug interactions
Azilsartan-chlorthalidone + Glipizide
Severity: Minor
Azilsartan-chlorthalidone and Glipizide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone can raise blood glucose and blunt the effect of sulfonylureas such as glipizide. Diabetes control may worsen, particularly with higher diuretic doses.
What this interaction means in plain words
Azilsartan-chlorthalidone and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and impaired insulin secretion and sensitivity oppose the hypoglycemic action of the sulfonylurea (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c when chlorthalidone is started or its dose changed, and increase the glipizide dose if needed. Check serum potassium periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azilsartan-chlorthalidone and Glipizide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azilsartan-chlorthalidone
Other interactions of Glipizide
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Glipizide?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorthalidone can raise blood glucose and blunt the effect of sulfonylureas such as glipizide. Diabetes control may worsen, particularly with higher diuretic doses.
How serious is the interaction between Azilsartan-chlorthalidone and Glipizide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when chlorthalidone is started or its dose changed, and increase the glipizide dose if needed. Check serum potassium periodically.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
