Drug interactions
Azilsartan-chlorthalidone + Hydrochlorothiazide
Severity: Moderate
Azilsartan-chlorthalidone and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone is already a thiazide-like diuretic, so adding hydrochlorothiazide duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypomagnesemia and volume depletion. The combination offers little added benefit and raises the risk of adverse effects.
What this interaction means in plain words
Azilsartan-chlorthalidone and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive inhibition of sodium-chloride reabsorption in the distal tubule with increased urinary potassium loss.
What to do
Avoid duplicate thiazide-type therapy and use only one agent. If both are given, monitor serum potassium, sodium and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone is already a thiazide-like diuretic, so adding hydrochlorothiazide duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypomagnesemia and volume depletion. The combination offers little added benefit and raises the risk of adverse effects.
How serious is the interaction between Azilsartan-chlorthalidone and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide-type therapy and use only one agent. If both are given, monitor serum potassium, sodium and renal function.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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