Drug interactions
Azilsartan-chlorthalidone + Methylprednisolone
Severity: Moderate
Azilsartan-chlorthalidone and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining chlorthalidone with a systemic corticosteroid can increase potassium loss and cause hypokalemia. Methylprednisolone has weak mineralocorticoid action, so the effect is generally smaller than with hydrocortisone.
What this interaction means in plain words
Azilsartan-chlorthalidone and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Methylprednisolone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide-type diuresis and corticosteroid effects.
What to do
Monitor serum potassium during concurrent therapy, especially with high-dose or prolonged steroid courses, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Methylprednisolone
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- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Methylprednisolone?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining chlorthalidone with a systemic corticosteroid can increase potassium loss and cause hypokalemia. Methylprednisolone has weak mineralocorticoid action, so the effect is generally smaller than with hydrocortisone.
How serious is the interaction between Azilsartan-chlorthalidone and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during concurrent therapy, especially with high-dose or prolonged steroid courses, and replace potassium as needed.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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