Drug interactions
Azilsartan-chlorthalidone + Sotalol
Severity: Major
Azilsartan-chlorthalidone and Sotalol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone-induced hypokalemia or hypomagnesemia increases the risk of QT prolongation and torsades de pointes with sotalol. Additive blood pressure and heart rate lowering can also occur.
What this interaction means in plain words
Azilsartan-chlorthalidone and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia and hypomagnesemia potentiate sotalol's QT-prolonging effect, plus additive hemodynamic effects.
What to do
Check and correct potassium and magnesium before and during treatment, and monitor ECG and QT interval. Consider an alternative antihypertensive or antiarrhythmic if electrolytes are hard to maintain.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Azilsartan-chlorthalidone
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Sotalol?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorthalidone-induced hypokalemia or hypomagnesemia increases the risk of QT prolongation and torsades de pointes with sotalol. Additive blood pressure and heart rate lowering can also occur.
How serious is the interaction between Azilsartan-chlorthalidone and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during treatment, and monitor ECG and QT interval. Consider an alternative antihypertensive or antiarrhythmic if electrolytes are hard to maintain.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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