Drug interactions
Azithromycin + Dolasetron
Severity: Moderate
Azithromycin and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin can prolong the QT interval and has been linked to torsades de pointes in at-risk patients. Together with dolasetron the additive effect may raise arrhythmia risk.
What this interaction means in plain words
Azithromycin and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Check baseline ECG in patients with cardiac risk factors and correct potassium and magnesium. Consider an alternative antibiotic or antiemetic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Dolasetron?
MediHelp rates the interaction as moderate. Azithromycin and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin can prolong the QT interval and has been linked to torsades de pointes in at-risk patients. Together with dolasetron the additive effect may raise arrhythmia risk.
How serious is the interaction between Azithromycin and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG in patients with cardiac risk factors and correct potassium and magnesium. Consider an alternative antibiotic or antiemetic in high-risk patients.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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