Drug interactions
Azithromycin + Estradiol
Severity: Minor
Azithromycin and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics were theorized to reduce enterohepatic recycling of estrogens, but evidence for meaningful loss of effect is weak. Clinical impact on estradiol is expected to be small.
What this interaction means in plain words
Azithromycin and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azithromycin belongs to Anti Bacterial; Estradiol belongs to Endocrine.
Why it happens
Theoretical alteration of gut flora reducing enterohepatic recirculation of estrogen.
What to do
No action is generally required; advise patients to report breakthrough bleeding or recurrence of menopausal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Azithromycin with Estradiol?
MediHelp rates the interaction as minor. Azithromycin and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics were theorized to reduce enterohepatic recycling of estrogens, but evidence for meaningful loss of effect is weak. Clinical impact on estradiol is expected to be small.
How serious is the interaction between Azithromycin and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required; advise patients to report breakthrough bleeding or recurrence of menopausal symptoms.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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