Drug interactions
Azithromycin + Fluconazole
Severity: Moderate
Azithromycin and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so used together they may increase the risk of torsades de pointes. Fluconazole risk is greater at higher doses and with renal impairment or electrolyte disturbances.
What this interaction means in plain words
Azithromycin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Fluconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Check ECG and correct potassium and magnesium in patients with additional risk factors. Consider an alternative agent if QTc is already prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Azithromycin with Fluconazole?
MediHelp rates the interaction as moderate. Azithromycin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so used together they may increase the risk of torsades de pointes. Fluconazole risk is greater at higher doses and with renal impairment or electrolyte disturbances.
How serious is the interaction between Azithromycin and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium in patients with additional risk factors. Consider an alternative agent if QTc is already prolonged.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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