Drug interactions
Azithromycin + Goserelin
Severity: Moderate
Azithromycin and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin can lengthen the QT interval, and azithromycin has a similar effect. Together they may raise the likelihood of torsades de pointes, especially in patients with other cardiac risk factors.
What this interaction means in plain words
Azithromycin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarization while azithromycin blocks hERG potassium channels.
What to do
Check a baseline ECG and electrolytes in patients with cardiac risk factors and monitor the QTc during the antibiotic course. Consider a non-QT-prolonging antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Azithromycin with Goserelin?
MediHelp rates the interaction as moderate. Azithromycin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin can lengthen the QT interval, and azithromycin has a similar effect. Together they may raise the likelihood of torsades de pointes, especially in patients with other cardiac risk factors.
How serious is the interaction between Azithromycin and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes in patients with cardiac risk factors and monitor the QTc during the antibiotic course. Consider a non-QT-prolonging antibiotic in high-risk patients.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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