Drug interactions
Azithromycin + Ozanimod
Severity: Moderate
Azithromycin and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and atrioventricular conduction, and azithromycin may prolong the QT interval, so combined use could raise arrhythmia risk. Bradycardia can further predispose to torsades de pointes.
What this interaction means in plain words
Azithromycin and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction: bradycardia from ozanimod plus QT prolongation from azithromycin.
What to do
Review ECG and heart rate before starting ozanimod and monitor during co-treatment; correct electrolytes and consider an alternative antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Azithromycin with Ozanimod?
MediHelp rates the interaction as moderate. Azithromycin and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and atrioventricular conduction, and azithromycin may prolong the QT interval, so combined use could raise arrhythmia risk. Bradycardia can further predispose to torsades de pointes.
How serious is the interaction between Azithromycin and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review ECG and heart rate before starting ozanimod and monitor during co-treatment; correct electrolytes and consider an alternative antibiotic in high-risk patients.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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